Charles Stanley, MD

Founder, Congenital Hyperinsulinism Center, and researcher

Stanley, a world-renowned expert on disorders of insulin regulation in children, received the Judson J. Van Wyk Prize, the Pediatric Endocrine Society’s most prestigious award for outstanding career achievement. He has helped define the various types of congenital hyperinsulinism (HI) and pioneered best practices for diagnosis and treatment of HI. Early diagnosis and treatment help prevent seizures and potential brain damage from dangerously low levels of glycemia. Determining the type of HI guides treatment, including a surgical cure for many children with the focal type.

Breakthrough moment

“In about 1998, we had figured out the genetics for focal HI, but locating the lesions was difficult. One day I saw [Surgeon-in-Chief] Scott Adzick in the cafeteria, and the answer just came out: ‘I know how we can find focal lesions.’ I had read that doctors in Finland were using 18F-DOPA PET scans to find insulinomas; I figured it would work for HI, too. That led to a collaboration between Endocrinology and Radiology that has resulted in the HI Center performing more than 250 diagnostic PET scans and curing more than 150 patients with focal HI.”

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